Urinary 17-KS, its fractions and urinary 17-OHCS in diabetes mellitus with vascular complications.

(Received for publication, April 25, 1959) It is no doubt that diabetes mellitus occurs as a result of deficiency in insulin due to hypofunction of the pancreatic Langerhans' islet cells, but no one nowardays would call diabetes mellitus a disease caused by a mere change in the Langerhans' islets. At present, diabetes mellitus is considered to be due to disturbance of some endocrine organsl)2)3) With recent striking advances in the chemistry of enzymes and hormones, the role of hormones in the metabolism of sugar is becoming more understood. In summary, the presently accepted antiinsulin system is something as follows.